Why fashion?

I’ve never been a fashion girl.

In fact, if you were to ask my childhood friends what I was like growing up, fashionable would come dead last after the many other adjectives that reference my distinct unfashionability, which include my love of basketball jerseys, backwards baseball hats, and a bizarre need to tuck my shirts fully into my pants, creating a sort of bulge around my waist where all the fabric hid.

What I studied in college

Aerial view of Vanderbilt University campus with historic brick buildings surrounded by trees with autumn foliage, set against a cityscape and distant hills.

My college experience was all about chemistry. After surviving the first few years of general chemistry and physics courses, which were purposefully difficult to help weed out any undeserving medical school hopefuls, I got into the good stuff. The second half of my undergraduate studies were filled with courses like analytical chemistry, medicinal chemistry, brain chemistry, and my all-time-favorite, physical chemistry.

I purposefully leave out physical organic chemistry, as this class humbled me more than anything else I’ve experienced to date. Think physics - thermodynamics, quantum mechanics, etc., - but for organic chemistry reactions. This one was not for me.

Now while my chemistry career ended upon graduation - I did think about pursuing a PhD, but the truth is, spending the rest of my life focused on exactly one receptor type felt more like a prison sentence than an achievement - I still think it’s the most interesting subject matter out there. And I’ll happily debate team physics on this any day.

So, in 2009, I left this behind for a career in finance and then for a career in tech and maybe one day for a career in something else, but the truth us, sometimes I feel like the “distracted boyfriend” meme where the other girl is the science life I didn’t choose.

Some research I did

For the last 2 years of collage, I worked as an undergraduate research assistant in the Neuroscience Drug Discovery lab at Vanderbilt. The focus of “my” research (“my” is loose here - I basically followed around a PhD candidate named Tom Bridges who told me what to do), was on developing a series of small compound potentiators to increase the activity of the M1 muscarinic acetylcholine receptor. This receptor is a promising target in the treatment of Alzheimer’s Disease and by selective activation of the M1 subtype, neurons that are still functional can potentially slow the progression of the disease by increased activity. That said, science moves fast, this was a very long time ago, so it’s possible none of this is true anymore :)

Christina Sarelakos
Diagram showing chemical reactions using isatin and benzylbromide derivatives with a graph illustrating M1 PAM-042 compound potency on acetylcholine potentiation.
Table and text detailing a chemical reaction scheme and reactant list. The table lists reactants: 5-Methylisatin, 5-Fluoroisatin, 5-Chloroisatin, and 2-Methylbenzylbromide. The text describes a library A1 reaction scheme using isatin substrates alkylated with benzylic reactants under microwave conditions, followed by purification through HPLC. It discusses synthesis, screening, and testing of compounds for their selectivity and activity in cellular assays, focusing on the optimization of compound M1 PAM-042.
Graph and table analyzing intracellular calcium mobilization in M1 and M5 cells with compound data from M1 PAM-042 Library Set A.
Chemical reaction scheme for reductive amination involving M1 PAM-042 and amines to form TMB-02-103-B1 Library compounds, with detailed procedural text and analysis description.
A page containing a paragraph about the importance of M1 and M5 muscarinic receptor ligands in pharmacological research and a list of four references, each detailing studies related to muscarinic receptors and drug development.